Develop and submit one three-generation pedigree from the case…

Develop and submit one three-generation pedigree from the case listed below.  The pedigrees will show the name, birth date/age of each family member.  Identify the generation and family members using Roman numerals for each generation and Arabic numbers for each family member starting at 1, left to right.

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Include disorders, age of onset and age of death if known

Develop a Key for identifying conditions, date of interview and interviewer

 

Maggie, Lily, Amanda, Michael and Roland’s parents are Lou Ann and Thomas.  Thomas is deceased from respiratory complications at age 56.  Thomas developed tremors and behavior changes since he was 35 years old and was non-ambulatory at the time of his death. Thomas’s younger sister, Joanne, age 62, has a history of learning disabilities.  Lou Ann is now 60 and has a history of hypothyroidism

 

 

After completing the pedigree, answer and submit these questions.

A. What mode of inheritance is Fragile X syndrome?

B. What are the characteristics of this mode of inheritance and transmission?

C. What would be the criteria and characteristics for a pre-mutation of Fragile X syndrome?

D. Who else in this pedigree could be probable carriers of the trait?

E. Are there any other patterns of inheritance in this pedigree?

F. What is the role of the nurse once the pedigree has been created?

Explanation & Answer

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